Guillain-Barré Syndrome in Adults in a Decade: The Largest, Single-Center, Cross-Sectional Study From the Kingdom of Saudi Arabia

Background: Guillain-Barré Syndrome (GBS) is the most common cause of acute, usually post-infectious, peripheral neuropathy resulting in a symmetrical, ascending paralysis. We evaluated clinical and neurophysiological features, treatment, outcomes patients with GBS our center. Methods: A retrospective chart review on admitted to King Abdulaziz Medical City, Riyadh, Saudi Arabia, from January 2011 December 2020. Data were analyzed using JMP statistical software version 15 pro. Results: total 86 who met criteria included, 55 (64%) males, mean age 49.5+/-17.5 years. Antecedent infection was reported 53 (61.6%), 51 (62.2%) presented within one week symptoms onset. Ascending weakness seen (70.5%), while 70 (81.4%) had areflexia. Acute motor axonal (AMAN) commonest electrophysiological type 41 (51.9%) patients. Albuminocytologic dissociation 48 (57%) lumbar puncture. Nearly half, (47.7%) intensive care unit (ICU). Seventy (81.3%) treated intravenous immunoglobulin. There no significant difference presentation, management, ICU requirement, discharge disposition between males females. Females more likely have higher disability at (p=0.01). Patients younger than 60 years require admission (p=<0.01). Conclusion: Our slightly older previously region. AMAN GBS. Younger need admission, whereas females severe disability.